BIDMCBeth Israel Deaconess Medical Center
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Led by co-first authors, Lixin Wan, PhD, a member of the Wei laboratory at BIDMC and Juxiang Cao, PhD, a member of the Cui lab at BUSM, their experiments showed that in normal circumstances, MC1R was binding to PTEN, a well-known tumor suppressor gene.
In the study, the BIDMC researchers pinpointed the fat gene and its effect in mouse models of human obesity and insulin resistance and reported supporting evidence from fat tissue samples from both lean and obese people.
Working with architects, planners, and interior designers at Steffian Bradley Architects (Boston), the project team reimagined the patient experience for BIDMC, a teaching affiliate of Harvard Medical School that handles more than 750,000 patient visits annually.
Alex Toker, PhD, chief of the Division of Signal Transduction in the Department of Medicine and Pathology and the Cancer Center at BIDMC and author of the paper, explained: "What chemotherapy does in triple-negative breast cancer -- for reasons we don't yet fully understand -- is reprogram this pyrimidine-biosynthetic pathway to really crank up production of these nucleotides.
Ciottone, director of the BIDMC Disaster Medicine Fellowship and associate professor of emergency medicine at Harvard Medical School, serves as the program's medical director.
But now, using cell-specific neuron-mapping techniques with mice, the BIDMC group discovered a strong excitement-producing drive that emanates from an area of the hypothalamus not previously thought to be involved in the hunger response--to the contrary, the brain region in question has long been associated with causing feelings of fullness.
In 2010, OpenNotes was piloted with primary care physicians at three, large health care organizations: BIDMC, Geisinger Health System in Pennsylvania, and the University of Washington Harborview Medical Center in greater Seattle.
Each year BIDMC conducts a survey to identify the needs of staff within individual departments.
The newly protected data includes more than 400 clinical and business applications, and a BIDMC custom clinical application called Center for Clinical Computing (CCC) that leverages InterSystems CACHE, an advanced object database that handles huge volumes of transactional data.