(2013) Disease-causing mutations in the XIAP BIR2
domain impair NOD2-dependent immune signalling.
XIAP, a member of IAP family with baculovirus IAP repeat (BIR) domain, has been shown to bind to and inhibit caspase-3 and caspase-7 via the BIR2
linker region, leading to alternation of cellular localization and blockage of the caspases docking to their substrates .
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