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BIRC3Baculoviral IAP Repeat-Containing 3 (inhibitor of apoptosis proteins, IAP)
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Watt et al., "Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report," Diagnostic Pathology, vol.
Other important factors that decide the cell fate are apoptotic protein inhibitors like BIRC2 and BIRC3 that inhibit the activity of caspase-3, caspase-7, and caspase-9 [42].
According to our study's findings, 17 mRNAs (MLH3, ACSL6, CD55, CR1, XRCC4, CTSK, KRAS, DDE3B, CCNB1, PAICS, SEC62, PSMD6, BIRC3, TCF7, NT6E, PSPH, and TRCP1) in PBMC of PLC patients with gan-shen Yin deficiency were different from those in PLC patients without gan-shen Yin deficiency [2].
Yu et al., "Gene network revealed involvements of Birc2, Birc3 and Tnfrsf1a in anti-apoptosis of injured peripheral nerves," PLoS ONE, vol.
Prognosis in Chronic Lymphocytic Leukemia Fluorescence In Situ Hybridization Approximate Marker Frequency Prognosis Del 13q14 35%-45% Low risk Trisomy 12 11%-16% Intermediate-high risk Del 11q22-23 (ATM; 10%-17% Intermediate-high risk BIRC3) Del 17p (TP53) 3%-7% High risk No abnormalities by Low-intermediate risk fluorescence in situ hybridization Marker Notes Del 13q14 Trisomy 12 Del 11q22-23 (ATM; Bulky disease, BIRC3) aggressive clinical course, shorter survival Del 17p (TP53) Frequently no response to therapy or relapse after therapy No abnormalities by fluorescence in situ hybridization
We also observed that the other two candidate genes BIRC2 and BIRC3 showed a significant decrease in histone H3K9me3 in MN patients compared with healthy subjects.
The fold change in the top 5 of the downregulated genes (Kitl, Pparg, Vegfc, Ptgs2, and Pdgfb) ranged from 24.57 to 5.95 and in the top 5 of the upregulated genes (Mmp2, Dapk2, Tcf7, Wnt1, and Birc3) from 6.91 to 3.18.
The genes NLRP1, CASP4, TLR2, TLR6, NF[kappa]B, HIF1A, and BIRC3 were significantly upregulated, and the Bcl2 gene was significantly downregulated (Table 2).
Moreover, these newly discovered novel gene mutations, such as NOTCH1 , SF3B1 , and BIRC3,[sup][23] have been reported to be associated with disease progression and may have critical role in predicting the TTFT,[sup][23],[31] but they are not routinely evaluated in our clinical laboratory and were therefore not included in the development of this prognostic index.