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BIRC5Baculoviral IAP (inhibitor of apoptosis protein) Repeat-Containing 5
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In both LIF-treated (Vitrified and non-vitrified) groups, the expression ratio of pro-apoptotic genes (Fas, FasL, caspase 3 and 8, and p53) was lower and the expression of anti-apoptotic gene (BIRC5) was higher than non-LIF-treated groups (p<0.05).
(d) RT-qPCR analysis for the mRNA levels of YAP targeted genes (Areg, Birc5, Ctgf, Cyr61, and Foxm1) (n = 3).
We selected TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1, which with worse overall survival situation according to the Kaplan-Meier plotter.
Viscum, TT, and viscumTT suppressed the expression of the inhibitor of apoptosis protein (IAP) family members XIAP and BIRC5. Further, incubation with viscum and viscumTT led to downregulation of BCL2 family members BCL2, BCL2L1, and MCL1 (Figure 4).
For the mRNAs, in comparison with the control group, the expression level of COL19A1, NOS2, C13orf15, FOS, SPINT1, and PLAC8 was upregulated to 10.331-, 31.374-, 7.534-, 12.573-, 24.758-, and 19.885-fold in BoNTA (5 U 24 h) treated groups, respectively (Figure 3), and the expression level of FCN2, BIRC5, and E2F1 was downregulated to 1.890-, 0.923-, 0.709-fold separately (Figure 3).
Rapamycin also decreased the mRNA levels of both FAS and CASP3; however, the expression of BCL2L1 and BIRC5 increased in blastocysts compared with untreated aged oocytes.
The genes were chosen to represent different biological pathways relevant for breast cancer biology, including hormone receptor status (ESR1, PGR), HER2 (human epidermal growth factor receptor 2) status for targeted antibody therapy (ERBB2), tamoxifen metabolism/detoxification (EPHX1), WNT signaling pathway (MMP7), angiogenesis (VEGFA), and proliferation (BIRC5, TOP2A).
In line with these observations, we found that PRL increases the expression of the BIRC5 (survivin) gene (see Supplementary Figure 1 in supplementary material available online at, which belongs to a family of apoptosis inhibitors (IAP) [44, 45].
The inhibitor of apoptosis protein (IAP) survivin, encoded by the BIRC5 gene, was highly expressed in all MM primary tumors (12 samples) and cell lines (7 of 8) compared with normal pleura.
We reported previously that the K14E6 mice activate the canonical Wnt pathway in the skin, as well as Wnt targets genes such as cMyc, CCND1, and BIRC5 in nonwounded skin biopsies [15].
Gains included regions containing genes previously described to be affected in ALCL, such as survivin (BIRC5) (17q25.3), HRAS (11p15.5), and HOXB (17q21.32).