BMCP1Brain Mitochondrial Carrier Protein-1
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Five UCPs have been characterized in mammals: UCP1UCP3 that are evolutionary related and UCP4 and UCP5 (also known as BMCP1) that are more divergent [3].
BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast.
UCP2 is the only ubiquitous isoform, whereas UCP3 is expressed in skeletal and cardiac muscles and shows 54 to 59% homology of amino acid sequence with UCP1; UCP4 has been found in kidney and central nervous system and UCP5, also called brain mitochondrial carrier protein (BMCP1), has been found in brain cells.