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Both children and adolescents with IR were significantly older and taller and had a higher weight and higher BMISDS (Tables 1 and 2).
We did not observe any changes in the BMISDS. The results observed are in accordance with studies on the introduction of advanced CHO content calculation, which state that it appeared to have variable influence on the BMI, with minor or no changes, as Schmidt et al.
In addition, serum ghrelin correlated negatively with BMISDS (r = -0.95, P < 0.001), TSFT (r = -0.88, P < 0.001), and SSFT (r = 0.83, P < 0.001) percentiles and hemoglobin (r = -0.68, P = 0.038) and serum albumin (r = -0.91, P < 0.001) and positively with ALT (r = 0.88, P = 0.001), AST (r = 0.85, P = 0.01), total bilirubin, and PT (r = 0.76, P = 0.01).
Higher ghrelin was associated with lower BMISDS and TSFT and SSFT percentiles but did not affect height SDS (Table 4).
The corresponding changes in BMISDS were -0.15 (-0.54-0.05) and -0.12 (-0.50-0.08) for the off label and RCT group, respectively (p = 0.99) (Figure 2).
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