BMP2Bone Morphogenetic Protein 2
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Compared to those at week 0, the BMP2 (p<0.05) (Figure 3C) and TGF[beta]-1 (p<0.05) (Figure 4A) transcript levels were significantly higher in 2-week-old animals and then gradually decreased thereafter.
* Lyophilized authentic human Polypeptide Growth Factors: Adiponectin, BMP2, EGF, FGF1, FGF2, FGF7, FGF10, Fallistatin, Gremlinl, hGH, hPL, Irisin, Midkine, PDGF, PRL, SCF, TGFb1, TGFb3, TIMP2, Thymosin-b4, VEGF, VIP
Bone morphogenetic protein 2 (BMP2), which showed significantly different expression in DF and NF in this study, has been shown to regulate primordial follicle formation by promoting the germ cell to oocyte transition and the somatic cell to pre-granulosa cell formation (Chakraborty and Roy , 2015).
Chris Christou [11] described that the immunohistochemical marker expression studies show BMP2 on the surface of membrane and TGF b in both surfaces of membrane and deeper tissues, VEGF in the membrane and blood vessels around the membrane.
Let-7g-5p HMGA2 [69] miR-10b-5p Bcl6 [80] miR-19a Undetected [64] miR-19b Smad7 [43] miR-21 FasL, PDCD4 [41, 42] miR-22-3p HDAC6 [68] miR-23a Fas, Runx2 [70, 71] miR-24 Tcf-1 [81] miR-27 APC [56] miR-29a-3p DKK1, Kremen2, sFRP2 [82] miR-30 family Smad1, Runx2, LRP6 [59] miR-100 BMPR2 [83] miR-124 Dlx5, Dlx3, Dlx2 [73] NFATc1, RhoA, Rac1 [73] miR-125 ErbB2 [63] miR-140-5p BMP2 [65] miR-142 APC [60] miR-148a Kdm6b [46] MAFB [45] miR-2861 HDAC5 [75] Table 3: miRNA dysregulated in plasma of osteoporotic patients and their function.
An example of the inverse correlation among miRNA and mRNA expressions could be observed for the Bmp2 gene in AIRmax mice.
Figure 2 shows the DSA residues between a BMP2 image and its corresponding images at the same azimuth in the template database comprised by BMP2, BTR70, and T72 (the detailed descriptions of these targets are presented in Section 4).
BMP2 is one of the strongest osteo-/odontogenic induction members in the BMP family, supporting osteo-/odontogenic differentiation of dental pulp stem cells [4,6,9].
It is accompanied by downregulation of contractile VSMC markers, such as alpha-smooth muscle actin (a-SMA) and smooth muscle 22 alpha (SM22[alpha]), and upregulation of various osteogenic transcription factors, such as runt-related transcription factor 2 (Runx2), Msx2, alkaline phosphatase (ALP), osteopontin (OPN), and bone morphogenetic protein 2 (BMP2) [5-8].
Within these genes, miR-378 may interact with apoptosis-related gene, like bone morphogenetic protein 2 (BMP2)(Liu et al., 2013), to regulate the cell fate of bGCs.
BMP2 alters the developmental pathway of NSCs from neurogenesis to astrogenesis by inducing negative helix-loop-helix (HLH) factors Id1, Id3, and a homologue of hairy and enhancer of split 5 (Hes5).
We created a dual cassette expression plasmid, encoding for both proangiogenic vascular endothelial growth factor 165 (VEGF165) and proosteogenic bone morphogenetic protein 2 (BMP2).