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BMP6Bone Morphogenetic Protein 6
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Excision of additional proteins HFE, TfR2, HJV or BMP6, or key component of the BMP receptor signalling pathwa y, excision of SMAD homolog 4 (SMAD4), results in poor and abnormal production of hepcidin.19 A study suggested that vegetarian children had a two-fold decrease in serum hepcidin level complemented by decreased ferritin level and small but statistically significant increase in concentration of soluble transferrin receptor (sTfR).
Temporal regulation of BMP2, BMP6, BMP15, GDF9, BMPR1A, BMPR1B, BMPR2 and TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
For the BMP6 treatment, the HepG2 cells were stimulated with 50 ng/mL BMP6 (PeproTech, Rocky Hill, Connecticut, USA) in the presence or absence of ASP (200 [micro]g/mL) for 24 hours.
The expression of RUNX2, osteocalcin (OCN), BMP2, or BMP6 mRNA was not detected at 5 days after transfection.
The findings that the expression level of BGLAP/osteocalcin gene is higher and the expression levels of BMP6, TGF-[beta]1, PTHLH, and PTN genes are lower in the hTERT-OA 13A FLSs compared to hTERT-RA 516 FLSs are consistent with the findings that the protein level of BGLAP/osteocalcin is significantly higher [46] and the protein levels of BMP6, PTHLH, PTN, and TGF-[beta]1 are significantly lower in the synovial fluid of OA patients compared to RA patients [43, 45, 47-49].
Immunoblotting was performed using antibodies against transformation growth factor (TGF-[beta]) (Santa Cruz, USA), bone morphogenic protein 6 (BMP6) (Bioworld Technology, Inc., USA), and 3-actin (Beijing Biosynthesis Biotechnology Co., Ltd.
The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice.
This factor is believed to be a protein called BMP6 or BMP7, members of a newly discovered family of axon guidance molecules.
In addition, growth/differentiation factor 9 and BMP6 were related to the regulation of MAPK pathway.
However, gene expression of aggrecan was higher in ASCs than in BMSCs in the presence of BMP6, while expression of chondrogenic markers was higher in BMSCs than in ASCs in the presence of TGF[beta].