Because the bed nucleus of the stria terminalis (BNST
), a limbic structure in the forebrain, is key to the translation of stress into sustained anxiety, factors that regulate its activity have untapped potential as novel therapeutic targets.
When a laser activated these BNST
neurons, the mice became ravenous, voraciously eating their food, the researchers report in the Sept.
also forms a bridge between the amygdala and the lateral hypothalamus, the brain region that drives primal functions like eating, sexual behaviour, and aggression.
Stuber wanted to focus on one cell type -- gaba neurons in the bed nucleus of the stria terminalis, or BNST
. The BNST
is an outcropping of the amygdala, the part of the brain associated with emotion.
According to Dr Santibanez et al (20), adrenalectomy decreases Corticotropin-Releasing Hormone (CRH) gene expression and increases noradrenaline and dopamine extracellular levels in the rat lateral bed nucleus of the stria terminalis (BNST
Structures examined included the caudate-putamen (CPu): central, dorsal, dorsomedial, and ventrolateral regions; cortex: cingulate, insular, and piriform regions; nucleus accumbens (nAcc): core and shell regions; lateral septal nucleus, ventral part (LSV); bed nucleus of the stria terminalis, lateral division, dorsal region (BNST
); thalamus: paraventricular nucleus (PV) and dorsomedial; amygdala: basolateral nucleus (BNA), central nucleus (CEA), and medial nucleus (MNA); hippocampal formation: dentate gyrus, CA1 and CA3 regions; and the premammillary nucleus.
neuropeptide Y) in the basolateral complex of the amygdala (Yilmazer-Hanke et al., 2002); (v) NGFI-A, which is induced in the amygdala as a consequence of fear, is strongly activated by acute amphetamine in the central nucleus of the amygdala in RLA-I rats, but not in RHA-I animals (Guitart-Masip et al., 2008); and, (vi) we have recently found that RLA-I rats also show enhanced CRF mRNA in the dorsal aspect of the bed nucleus of the stria terminalis (BNST
) (Carrasco et al., 2008).
Our work suggests that an interaction between these systems within two functionally and anatomically related limbic brain structures, the bed nucleus of the stria terminalis (BNST
) and the central nucleus of the amygdala (CeA), may mediate the effects of stress on relapse to drug seeking.
Two brain regions subject to alcohol's effects on synaptic plasticity are the striatum and bed nucleus of the stria terminalis (BNST
), both of which have key roles in alcohol's actions and control of intake.
(4) The affected brain regions include the prefrontal cortex and a group of structures known as the extended amygdala, including the central nucleus of the amygdala and the bed nucleus of the stria terminalis (BNST
Briefly, Numan describes the hormonal-primed medial preoptic area (MPOA) with the adjacent bed nucleus of the stria terminalis (BNST
) as central region to induce the onset of maternal behavior by suppressing fear responses to pup odors on the one hand and activating the nonspecific motivational system (i.e., the mesolimbic dopamine system) on the other hand.