Offspring were followed every 6 to 12 months for BPb measures, neurocognitive development, and physical examinations until age 12.5.
BPb levels were analyzed using a Graphite Furnace Atomic Absorption Spectrophotometer (GFAAS), model AAnalyst 600 (Perkin-Elmer, Shelton, CT) using a method modified after .
Linear regression was used to model associations between BPb and BP, sICAM-1, and sVCAM-1 controlling for ethnicity, sex, body mass index (BMI), smoking history, employment status, and education.
BPb measures were available for each subject from birth through 12.5 years of age, and at the follow-up.
Mean BPb concentrations remained significantly higher in Mitrovica residents than in those from Prishtina, even though the lead smelting plant drastically diminished its operations in the late 1990s and closed at the onset of the war in 1999.
Results from the regression models relating BPb to sBP and dBP are shown in Table 3.
To test these three potential pathways, we examined the associations between BPb and measures of [FT.sub.4], TSH, and TPOAb in data collected during the Yugoslavia Prospective Study of Lead Exposure, Pregnancy Outcomes, and Child Development (Graziano et al.
A total of 1,502 women were recruited: 602 from Mitrovica, a town with a lead smelter, refinery, and battery plant in which high BPb concentrations had been reported in both adults and children (Popovac et al.
Mid-pregnancy maternal serum samples were assayed for BPb according to methods described previously (Factor-Litvak et al.
We natural log (ln)-transformed BPb, TSH, and TPOAb to meet assumptions of the statistical models and to reduce the influence of extreme values.
At recruitment, the 291 subjects used in this analysis were similar to the 420 members of the cohort who did not meet the inclusion criteria in terms of age, education, number of prior live births, mid-pregnancy BPb and Hgb levels, and fetal gestation age at mid-pregnancy blood draw.