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A single or repeated BPEE preadministration to rats with 6 h of WIRS attenuated the increases in gastric mucosal LPO and NOx concentrations and XO activity significantly and the repeated BPEE preadministration further attenuated the increase in gastric mucosal MPO activity significantly (Figure 4).
When rats preadministered with BPEE in a repeated manner and a single manner or rats preadministered with VE in a single manner were exposed to 6h of WIRS, serum ACTH, CORT, and glucose concentrations in stressed rats preadministered with BPEE in a repeated manner and in a single manner or rats preadministered with VE in a single manner were not significantly different from those in stressed rats with any preadministration (Figure 5).
Our previous report has shown that a single preadministration of BPEE (50 mg/kg, p.o.) to Wistar rats protects against gastric mucosal lesions induced by 6 h of WIRS more effectively than a single preadministration of the extract (10 mg/kg or 100 mg/kg, p.o.) .
A single preadministration of BPEE (50 mg/kg, p.o.) attenuated the increased gastric mucosal LPO and NOx concentrations and XO activity and the decreased gastric mucosal NPSH, VC, and VE concentrations, but not the increased gastric mucosal MPO activity, as shown in our previous report .
We have reported that 40 pg or more of BPEE inhibits XO activity in vitro .
Therefore, it is suggested that repeatedly preadministered BPEE (50 mg/kg/day) could attenuate increased gastric mucosal LPO concentration in rats with 6 h of WIRS through its antioxidant action, which is possibly mainly due to artepillin C present in the extract.
We have reported that 10 pg or less of BPEE inhibits the production of [O.sub.2-.sup.-*] in activated human neutrophils without scavenging the produced [O.sub.2]- .
Therefore, there seems to be a possibility that BPEE (50 mg/kg/day.
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