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Related to BRCA1: BRCA2
BRCA1Breast Cancer Gene 1
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"Previous research has shown us that in cells the BRCA1 gene makes a protein that helps repair damage to broken DNA.
Prophylactic bilateral oophorectomy (BO) reduces the risk of future ovarian cancer in women who have BRCA1 gene mutations.
Tabrizi also said that breast and ovarian cancer risk before the age of 30 is relatively low, even for carriers of BRCA1 and BRCA2 mutations.
Patients who agreed to BRCA1 and BRCA2 genetic testing were asked to complete a questionnaire regarding their family histories.
"Rather than being a barrier to transitioning, genetic counseling can benefit transgender individuals at risk for BRCA1 or BRCA2 mutations by helping them understand their cancer risks and the choices available to them to manage those risks," says Sacca.
"Knowing that BRCA1 or BRCA2 mutations do not result in a different prognosis might change the therapeutic approach.
Genistein is the predominant isoflavone found in soy and it may actually block DNA methylation, the silencing of the BRCA1 gene.
While mutations of BRCA1 and BRCA2 were detected in five and five breast cancer cases respectively, they were one and two in individuals at risk.
Mutational spectrum in breast cancer associated BRCA1 and BRCA2 genes in Colombia
Of all breast cancer cases, between 1% and 5% are the result of inherited mutations in BRCA1 or BRCA2 genes.