Dose-response experiments suggested that BTCI was capable of inducing changes in renal function.
BTCI pretreatment promoted a significant increment in the variation of fractional [Na.
Since BTCI is a medium size protein, it must be filtered by the glomerulus.
The fact that guanylin undergoes renal metabolism and that BTCI enhanced guanylin-induced natriuresis may explain the observation made by Fonteles et al.
Both amino acid sequencing and 3-D spatial modeling have demonstrated that BTCI share strong structural homology with other members of the Bowman-Birk family of protease inhibitors.