These 11 genes were Gbx2, KI67, CCNB1, BUB1
, KNTC2, USP22, HCFC1, RNF2, ANK3, FGFR2, and CES1.
The investigators do not have direct proof that mutations in the human BUB1
lead to aneuploidy, although they do have evidence that the mutant gene enables human cells to proceed with aspects of cell division after being treated with drugs that disrupt spindle assembly.
mediation of caspase-independent mitotic death determines cellfate.