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BHLHBasic Helix-Loop-Helix
BHLHBig Head Little Head (band)
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* The report provides a snapshot of the global therapeutic landscape for Myc Proto-Oncogene Protein (Proto-Oncogene c-Myc or Class E Basic Helix-Loop-Helix Protein 39)
* The report reviews Myc Proto-Oncogene Protein (Proto-Oncogene c-Myc or Class E Basic Helix-Loop-Helix Protein 39) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Gass et al., "Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice," The Journal of Neuroscience, vol.
Takahashi et al., "Prg1 is regulated by the basic helix-loop-helix transcription factor Math2," Journal of Neurochemistry, vol.
Heimrich et al., "Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus," Journal of Neuroscience, vol.
Chiaramello, "Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration," Journal of Neuroscience Research, vol.
Chiaramello, "The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an antioxidant response and sustaining the mitochondrial biomass," ASN Neuro, vol.
Shahdat et al., "Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells" Neuroscience, vol.
Kageyama, "Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain," The Journal of Biological Chemistry, vol.
As-NURP1 also contained a basic helix-loop-helix DNA binding domain consisting of the conserved peptides: basic, 26-GRLRTK-31; helix I, 32-QEAALHT-38; loop, 39-NRFDPSG-45; and helix II, 46-HSRKLVTKM-54 (Fig.
As-NURP1 is devoid of known signal peptide sequences or transmembrane regions and contains a basic helix-loop-helix (bHLH) motif and a nuclear localization signal sequence, which are consistent with other nurpl proteins.
Abbreviations: bHLH, basic helix-loop-helix: NURP1, nuclear protein 1.
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