(BITC) triggers mitochondria-mediated apoptotic machinery in human_cisplatin-resistant_ oral cancer CAR cells.
Concentrations of the bioactive condensed tannins (proanthocyanidins), L-dopa, and benzyl isothiocyanate
in the lespedeza hay, mucuna seeds, and papaya seeds were within normal ranges of 8.7% to 18.1% , 2.2% to 5.4% , and 2 to 687 mg/kg , respectively.
The root extract also possesses antimicrobial activity attributed to the presence of 4-a-L-rhamnosyloxy benzyl isothiocyanate
Putsep, "Benzyl isothiocyanate
, a major component from the roots of Salvadora persica is highly active against Gram-Negative bacteria," PLoS ONE, vol.
Dietary chemopreventative benzyl isothiocyanate
inhibits breast cancer stem cells in vitro and in vivo.
exhibits anti-inflammatory effects in murine macrophages and in mouse skin.
Anuradha Sehrawat, Ph.D., will discuss how breast cancer stem cell growth is inhibited when a protein called Ron sensitizes the stem cells to the benzyl isothiocyanate
molecule in cruciferous vegetables.
A compound present in crushed papaya seed that is believed to have activity against helminthic intestinal parasites, benzyl isothiocyanate
(BITC), has been shown to have an effect on vascular contraction using a canine carotid artery in vitro model .
Wattenberg, L.W., Inhibitory Effect of Benzyl Isothiocyanate
Administered Shortly Before Diethylnitrosamines or Benzo[[Alpha]]pyrene on Pulmonary and Forestomach Neoplasis in A/J Mice', Carcinogenesis (Lond.), 8:1971-1973, 1987.
The purpose of this study was to investigate the antimicrobial effect of bee venom and its major component melittin alone or in twoand three-drug combinations with antibiotics (vancomycin, oxacillin, and amikacin) or known antimicrobial plant secondary metabolites (carvacrol, benzyl isothiocyanate
, sanguinarine, and berberine; Fig.
And garden cress, cabbage, and Indian cress are top sources of a glucosinolate known as glucotropaeolin, the precursor of benzyl isothiocyanate
Anti-proliferative and proapoptotic effects of benzyl isothiocyanate
on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.