BRONJ

(redirected from Bisphosphonate-Related Osteonecrosis of the Jaw)
AcronymDefinition
BRONJBisphosphonate-Related Osteonecrosis of the Jaw (also seen as BROJ)
References in periodicals archive ?
Intravenous bisphosphonate-related osteonecrosis of the jaw: bone scintigraphy as an early indicator.
Burr, "The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data," Journal of Oral and Maxillofacial Surgery, vol.
Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol 2009; 27: 5356-62.
A position paper on Medication Related Osteonecrosis of the Jaw (MRONJ), released by the American Association of Oral and Maxillofacial Surgeons, expands the scope of the condition previously referred to as Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) and changes its name to reflect the antiresorptive (denosumab) and antiangiogenic therapies that have recently been associated with the condition.
These results are based on a study carried out at Israel's Tel Hashomer Medical Center, which aimed to find the unique genetic profile that allows evaluating the risk among cancer patients of developing the adverse event, bisphosphonate-related osteonecrosis of the jaw (BRONJ) and to be used as the basis for developing a novel diagnostic assay.
Cha et al., "Oral bisphosphonate-related osteonecrosis of the jaw: the first report in Asia," Osteoporosis International, vol.
Marin et al., "Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytoehrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis," Blood, vol.
However, in recent years, bisphosphonate-related osteonecrosis of the jaw (ONJ) has also appeared in the literature as a rare but serious side effect of bisphosphonate therapy, although a direct causative relationship has not been demonstrated.
In this study, the creation of an animal (rat) model of bisphosphonate-related osteonecrosis of the jaw that resembles the human disease suggests that vitamin D insufficiency plays a crucial role in the disease's manifestation and severity.
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first reported, in 2003, and since that time there have been numerous case reports published worldwide.
Liao et al., "Intravenous bisphosphonate-related osteonecrosis of the Jaw: bone scintigraphy as an early indicator," Journal of Oral and Maxillofacial Surgery, vol.
(4.) Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons.