A third aim of the trial was to evaluate the effectiveness of the newer versus older blood pressure lowering treatment
in patients with high blood pressure and high cholesterol (above 6.5 mmol/l).
The study was conducted by the Blood Pressure Lowering Treatment
Trialists' Collaboration and results were published in The Lancet in 2003.
Over a five-year period, the cost of using aspirin was pounds 3,500 and pounds 12,500 for initial blood pressure drugs, rising to pounds 18,300 for an intensive course of blood pressure lowering treatment
An unusual methodology adds both strengths and a potential weakness to the study by the Blood Pressure Lowering Treatment
In addition, a meta-analysis of 29 randomized trials (n=162,341) in the Blood Pressure Lowering Treatment
Trialists' Collaboration Trial (BPLTTC) (4) showed that all antihypertensive drug classes significantly reduce blood pressure.
It is hypothized that further diuretic therapy with spironolactone will be more effective at lowering blood pressure than alternative blood pressure lowering treatments
. Currently in UK it is also being discussed whether we should use renal denervation therapy.