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BMNCBone Marrow Mononuclear Cells
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Decreased ratio of HPCs (B) and HSCs (C) in iron overload (Fe) bone marrow mononuclear cells (BMMNCs) reversed by deferasirox (DFX) or N-acetyl-L-cysteine (NAC).
Araujo et al., "Intraarterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke," Cell Transplantation, vol.
Treatment with VP-16 and the combination of VP-16 with 1FN upregulated TRAIL expression in the bone marrow mononuclear cells of patients with acute leukemia at 24 h after the treatment, as compared with that in the control group (p<0.05).
Rapp et al., "Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia," Journal of Vascular Surgery, vol.
Cox et al., "Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells," Stem Cells, November 2016 DOI: 10.1002/stem.2538
Tu et al., "Direct antiglobulin test of bone marrow mononuclear cells: results of 270 cases with autoimmune hemocytopenia," Chinese Journal of Practical Internal Medicine, vol.
Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction.
The first study, conducted by Brazilian researchers, found that cell transplantation of bone marrow mononuclear cells (BMMCs) directly into the heart benefited patients suffering from refractory angina.
In these studies, the cell therapy group was one of the following stem cells: bone marrow mononuclear cells (BMMNCs, n = 7 studies), bone marrow mesenchymal stem cells (BMMSCs, n =4 studies), bone marrow stem cells (BMSCs, n =5 studies), peripheral blood mononuclear cells (PBMNCs, n = 2 studies), peripheral blood stem cells (PBSCs, n = 4 studies), CD34+ (n =1 study), or CD133+ stem cells (n =1 study).
Citation: Fernandes and Chong et al., "Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair," Stem Cell Reports, October 2015 DOI: 10.1016/j.stemcr.2015.09.011
Those conditions that cannot be successfully treated with cells derived from autologous bone marrow mononuclear cells (BMMNCs), are also likely to represent strong future opportunities in the stem cell market.
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