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Brenner, "The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis," Journal of Hepatology, vol.
By experimenting with bone marrow-derived stem cells, the researchers sought to exploit the rich source of stem cells in bone marrow.
(2006) have reported strong expression of CD90 in adult human bone marrow-derived stem cells, studies with bone marrow and adipose-derived canine mesenchymal stem cells (TAKEMITSU et al., 2012) and with canine umbilical cord blood- derived mesenchymal stem cells (SEO et al., 2009) have showed low expression of this marker.
Freeman, "The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders," Progress in Neurobiology, vol.
The bone marrow-derived stem cells were engineered to express insulin-like growth factor 1, which help bones grow in strength and size.
During that same meeting, the Colorado scientists also described 15 horses with injured joints that had exhausted all other treatment options--their lameness appeared irreparable--before receiving treatment with bone marrow-derived stem cells. With follow-up times ranging from 6 months to 18 months, 10 of the animals were able to return to their previous level of work.
In one study by Brehm and Strauer, bone marrow-derived stem cells were transplanted directly into the heart tissue of 18 male patients who had suffered a heart attack between five months and 8.5 years earlier.
Others examine multipotent stem cells from skin dermis, therapy for type 1 diabetes mellitus, and bone marrow-derived stem cells for cardiac repair and regeneration.
Kocsis and his group expect to learn a great deal more about the potential of bone marrow-derived stem cells to repair MS damage from studies of spinal cord injury repair now going on at Tulane University Medical Center.
Repair of infarcted myocardium has been demonstrated in experimental models of acute myocardial infarction (AMI), with both improved myocardial function and survival, following local administration of bone marrow-derived stem cells (BMSC) (5-8).
Friedlander, "Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis," Nature Medicine, vol.
The REGENERATIVE-IHD trial is the largest, randomized, placebo-controlled clinical trial in the U.K., to date, to investigate the use of autologous bone marrow-derived stem cells to improve cardiac function and symptoms in heart failure patients.