Creolin[R] has the ability to inhibit the development of local symptomatology when mixed with Bothrops jararaca venom
. However, in isolation, it does not present properties useful for the treatment of bothropic poisoning and may present potentially toxic adverse effects to the animals due to the variable sensitivity among the species.
Anti-hemorrhagic activity of four Brazilian vegetable species against Bothrops jararaca venom
. Molecules 2009; 14: 1072-1080, doi: 10.3390/molecules14031072.
In one study it was illustrated that Bothrops jararaca venom
proteases activated plasma kininogens to bradykinin, an inflammatory mediator responsible for vasodilation (and thus oedema) at the site of inflammation .
Crampton, "Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom
. Insights into the disintegrin gene family," The Journal of Biological Chemistry, vol.
Pharmacological evaluation of rat paw edema induced by Bothrops jararaca venom
. Agents and Actions 26: 292-300.
Detection of an antibothropic fraction in opossum (Didelphis marsupialis) milk that neutralizes Bothrops jararaca venom
. Toxicon 37, 167-172.