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References in periodicals archive ?
A 3-level, 3-factor, 17-run experimental Box-Behnken design was employed to optimize the norfloxacin pellets in terms of sphericity and hardness required to attain effective coating subsequently.
Critical process parameters are chosen based on literature and a design matrix is developed employing Box-Behnken design of experiment approach.
The significant independent variables glucose (X1), yeast extract (X2) and K[H.sub.2]P[O.sub.4] (X3) were selected for further optimization method (Box-Behnken design) as shown in Table (4).
A three-variable, three-level Box-Behnken design (BBD) was employed in this optimization study based on the results of preliminary experiments.
In this study, the effect of the amount of GO ([z.sub.1]), number of cycles ([z.sub.2]), and scanning rate ([z.sub.3]) on the peak current of ErGO/GCE was studied using the Box-Behnken design [38-40].
(2) Optimization of Extraction Conditions by a Box-Behnken Design. On the basis of the single-factor experiments, three levels were confirmed for the three factors, and then, a Box-Behnken design (BBD) of three variables (A, extraction time; B, concentration of ethanol solution; and C, ratio of solvent to material) and three levels (Design-Expert software, Trial Version 8.0.6, State Inc., Minneapolis, USA) was introduced to optimize the extraction procedure of the flavonoid fraction from A.
Using the independent variables and the corresponding levels for the Box-Behnken design shown in Table 1, the experimental results are presented in Table 3.
Abbreviations CSP: Carrot seed protein DPPH: 1,1-Diphenyl-2-picrylhydrazyl DRSA: DPPH radical-scavenging activity RSM: Response surface methodology BBD: Box-Behnken design ANOVA: Analysis of variance CSPH: Carrot seed protein hydrolysate DH: Degree of hydrolysis Vc: Vitamin C (L-ascorbic acid).
Box-Behnken Design. According to the principle of the Box-Behnken design, material-to-solvent ratio, ultrasonic time, and ultrasonic power were identified to have strong effects on the response in preliminary one-factor-at-a-time experiments.
Second, various parameters of DESs-UAE in extracting resveratrol were optimized and systematically evaluated using a Box-Behnken design.
Variables used in Box-Behnken design Levels Independent variable -1 0 1 Applied voltage (kV) 13 14 15 Flow rate (ml/hr) 0.05 0.2 0.35 Concentration (%w/v) 0.1 0.4 0.7 Dependent variables Constraints [Y.sub.1] = particle size (nm) Minimize [Y.sub.2] = size distribution Minimize Table 2.
A Box-Behnken design matrix shown in Table IV consisting of 14 sets of coded conditions was selected to conduct the experiments.