Diabetes was found to increase VEGF expression and release in primary brain microvascular endothelial cells
Escherichia coli K1 invasion increases human brain microvascular endothelial cell
monolayer permeability by disassembling vascular-endothelial cadherins at tight junctions.
Forster, "Differential susceptibility of cerebral and cerebellar murine brain microvascular endothelial cells
to loss of barrier properties in response to inflammatory stimuli," Journal of Neuroimmunology, vol.
A human brain microvascular endothelial cell
line (HBMEC) were seeded at 60%-70% confluence and kept at 37[degrees]C in 5% C[O.sub.2].
Shim, "Oxidative stress induced by cigarette smoke extracts in human brain cells (T98G) and human brain microvascular endothelial cells
(HBMEC) in mono- and co-culture," Journal of Toxicology and Environmental Health.
Connexin 30.3 expression has been demonstrated in nonBBB endothelial tissue, but there is currently no record of it being expressed by either astrocytes or brain microvascular endothelial cells
. Thus, the absent expression of GJB4 in this study is consistent with literature findings, confirming that neither model expresses barrier proteins not present at the BBB.
Studies have shown that high levels of free fatty acids induced oxidative stress, which damaged human brain microvascular endothelial cells
and resulted in apoptosis .
Gladson, "Thrombospondin-1-Induced apoptosis of brain microvascular endothelial cells
can be mediated by TNF-R1," Journal of Cellular Physiology, vol.
Emulates Brain-on-Chip demonstrated the physiologically-relevant modeling of the human brain's microenvironment, including successful co-culture of human brain microvascular endothelial cells
, neurons and astrocytes.
To date, very little information is available regarding the adhesive interactions that take place between tumor cells and brain microvascular endothelial cells
. Previously, we (40) generated an extensive library of tissue specific microvascular endothelial cell lines from H-2[K.sup.b]-tsA58 transgenic mice to study how tumor cells interact with endothelial cells from different anatomic regions.
coli DH5[alpha] harboring pOrl-1-CTX-M-1 were tested for invasiveness in human brain microvascular endothelial cells
(10) and in a newborn mouse (C57BL/6 wild-type) model of meningitis (R.