Matsuzaki et al., "Interferon-[gamma] down- regulates expression of the 230-kDa bullous pemphigoid antigen
gene (BPAG1) in epidermal keratinocytes via novel chimeric sequences of ISRE and GAS," Experimental Dermatology, vol.
Pathogenesis of PG involves the production of IgG1 antibodies against NC16A domain of carboxyl terminus of Bullous Pemphigoid Antigen
2 (BPAg2), leading to activation of complement, recruitment of eosinophils to the local site and damage of the basement membrane and consequent blistering.
Although lichen planus pemphigoides and bullous pemphigoid manifests in different ways clinically, the same antigen may be involved in immunopathogenesis of these two diseases (Bullous pemphigoid antigen