Comparison of butyrylcholinesterase
and acetylcholinesterase Biochem J; 260(3): 625-34 (1989).
The screening of all the synthesized compounds against butyrylcholinesterase
enzyme revealed that only three compounds showed good activity, N-benzyl-N-(3-hydroxyphenyl)-2,3-dihydrobenzo[1,4]dioxine-6-sulfonamide (6c), N-benzyl-2,3-dihydrobenzo[1,4]dioxine-6-sulfona-mide (3d), N-benzyl-N-(3,5-dimethylphenyl)-2,3-dihydrobenzo [1,4] dioxine-6-sulfonamide (6a) having IC50 values of 71.27+-0.01, 198.21+-0.11 and 259.61+-0.01 umoles/L respectively, comparative to eserine (Table 2).
Since the first biosensor is based on acetylcholinesterase or butyrylcholinesterase
in 1980s, it has been a continuous improvement of cholinesterase based biosensors due to the gradual improvement of transducer devices and the availability of pure enzymes [5-7].
(BChE) is an important enzyme synthesized in the liver.
RHT is a cholinesterase inhibitor that inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase
(BuChE) enzymes responsible for the degradation of acetylcholine (ACh) into nonfunctional metabolites.
leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase
activities in rat brain," Fitoterapia, vol.
This is due to the inhibition of the enzymes, butyrylcholinesterase
(BuChE) and acetylcholinesterase (1,29).
Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase
(BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology.
The commonly measured cholinesterases are butyrylcholinesterase
(BuChE) and red cell cholinesterase.
In vitro reactivation of trichlorfon- inhibited butyrylcholinesterase
using HI-6, obidoxime, pralidoxime and K048.