Go-Ahead, operator of Thames Trains - one of the companies involved in last year's Paddington rail disaster - said
C3D, which launched a pounds 326 million bid for the group in July, did not understand the business.
Caption: Figure 1: HLA antigens recognized by
C3d and/or C1q positive DSAs in the 39 dnDSA-positive patients.
To test whether C3b or its fragment
C3d could compete with X52.1 in binding to FH, we used a sensitive surface plasmon resonance analysis.
The enzyme immunoassay for ProMBP/C3dg complexes was performed as for the ProMBP/Ang complex with the modification that calibrators of 3.9, 7.8, 31.25, 125, 500, and 1000 mIU/L were used, and the detection antibody was HRP-conjugated rabbit anti-human complement
C3d (cat.
One of
C3D's main businesses is Transdev, an operator of buses and light rail networks in France and Britain.
In the C3d-based ELISAs, a monoclonal aC3d antibody or a monoclonal aC3bi,
C3d.g antibody is used to detect CICs.
(6) Products of complement activation in AMI include
C3d, C4d, and C5b-9.
Israeli company
C3D is trying another twist: using materials which are fluorescent and glow when regular light is shone on them.
Once activated, the complement cascade generates C3 cleavage products (C3b, iC3b, and
C3d) which attach covalently to the activating agent and serve as ligands for complement receptors type 1 (CD35) and type 2 (CD21) on human B cells.
Immunofluorescence demonstrated 1+ to 2+ granular staining for
C3d and C1q in a diffuse, peripheral, and segmental pattern; 1+ staining for immunoglobulin (Ig) M in a similar pattern and distribution; 1+ linear, peripheral staining for IgA; traces of fibrinogen; and absent staining for IgG.