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Likewise, C5a receptor inhibitor proved to be steroid-sparing in relapsing ANCA-associated vasculitis in a recent prospective randomized placebo-controlled trial .
It works by inhibiting C5a receptors in leukocytes, including neutrophils.
Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis.
Fisette et al., "C5a receptor deficiency alters energy utilization and fat storage," PLoS ONE, vol.
Davies et al., "TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2," European Journal of Immunology, vol.
A direct interaction of Gc-globulin with the C5a receptor as explanation for its cochemotactic effect was excluded by experiments showing that Gc-globulin does not alter the affinity of C5a for the C5a receptor (29).
The agreement between G2 Inflammation Pty Ltd., a subsidiary of G2 Therapies Limited, and Novo Nordisk A/S, will see both companies collaborate to develop, manufacture and commercialize new therapies based on G2's C5a Receptor antibodies.
Promics' drug PMX-53 acts by blocking the C5a receptor which acts earlier in the immune and inflammatory process than the targets of conventional anti-inflammatory drugs.
(Rockville, MD) has patented a human C5a receptor polypeptide and DNA encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques, as well as methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide.
Burwell et al., "Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis," Journal of Experimental Medicine, vol.
The company said Avacopan (CCX168) is an orally-administered small molecule that is a selective inhibitor of the complement C5a receptor, or C5aR.
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- C5 malignant
- C5 malignant
- C57Bl/6 Mouse Embryo Fibroblast
- C5a anaphylatoxin chemotactic receptor C5L2
- C5a receptor
- C5DELq14.3; DEL5q14.3
- C6 beta-chemokine