Study leader Nicolette Ognjanovski, of the Department of Molecular, Cellular, and Developmental Biology at Michigan, and colleagues found that disrupting the rhythm of neuronal firing, or oscillations, in the CA1
of mice interfered with memory formation, Health news reported,
They developed experiments to record CA1
activity in mice that were genetically modified to mimic schizophrenia, and compared them to normal, healthy mice.
To examine changes in glial cells in the CA1
following TGCI, immunohistochemistry for astrocytes and microglia was performed using mouse anti-glial fibrillary acidic protein (GFAP, 1:800, Chemicon) and rabbit anti-ionized calcium binding adapter molecule 1 (Iba-1, 1:800, Wako), respectively, according to the above-mentioned method.
During the kindling process, the LFPs in the MDT and CA1
were recorded at a sampling frequency of 1000 Hz and stored for offline analysis.
The layers of interest were the strata pyramidale, radiatum, and lacunosum molecular of CA1
, of the dorsal hippocampal formation.
The researchers were able to establish that without the input from mPFC through NR, the CA1
also loses its code for upcoming choice of trajectory.
activity between males and the other experimental groups were found in dorsal hippocampal region: CA1
(p < .
Se evaluaron 12 tratamientos mas dos testigos [TI: EG + 1, T2: EG + 2, T3: EG + 3, T4: CA1
+ 1, T5: CA1
+ 2, T6: CA1
+ 3, T7: CA2 + 1, T8: CA2 + 2, T9: CA2 + 3, TIO: PIN + 1, Til: PIN + 2, T12: PIN + 3, T13: testigo (urea, 120N ton [ha.
In another study of I/R in rat cerebrum, nuclear chromatin condensation and neuronal shrinkage in the hippocampal CA1
was observed after 7 days (20), which is similar to our results where significant morphological changes and density of the nuclear substance was evidenced (Figure 2A3c).
In addition, Simvastatin (10, 20, and 40mg/kg) significantly reduced the total number of abnormal pyramidal cells in CA1
and CA3 hippocampal regions compared to the picrotoxin-alone group.
In global cerebral ischemia, increased production of ROS has been regarded as an underlying factor for mediating delayed neuronal death, especially to pyramidal neurons in the hippocampal CA1
area (Hara et al.
In the old male rats normally nourished or malnourished prenatally, hemispheric asymmetry was addressed in the CA1
and CA3/CA2 subfields of hippocampal formation (9).