CAEBVChronic Active Epstein-Barr Virus
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In addition to ENKL, the lymphocyte variant HE is also reported to accompany chronic active Epstein-Barr virus (CAEBV) infection, with EBV-infected TV beta 5.1 T-cell clones identified as causing the overproduction of Th2 cytokines [8].
EBV is a member of the herpes virus family.1 Infectious mononucleosis caused by primary infection of EBV is a self-limiting lymphoproliferative disease, and shows concomitant clinical features such as pyrexia, cervical lymphadenopathy, liver dysfunc-tion and hepatosplenomegaly.1 In rare cases, EBV establishes a latent infection in B lymphocytes and runs a chronic course and shows infectious mononucleosis like symptoms repeatedly.2,3 This syndrome, named chronic active Epstein-Barr virus infection (CAEBV), carries a very poor prognosis, and most CAEBV patients die from haematological or non-haematological disorders within a few years.4,5