CASP3


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AcronymDefinition
CASP3Critical Assessment in Structure Prediction (third experiment)
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Conclusions: Dioscin inhibited tumor growth via inducing apoptosis, which was accompanied by altered expression of apoptotic pathway proteins, such as TP53, BAX, BCL2 and CASP3.
Western blot analysis of TP53, BAX, BCL2 protein expression and CASP3 cleaved levels
To verify these results, we further investigated the protein levels of BAX, BCL2 and proenzyme form of CASP3 in CA3 region of the hippocampus [Figure 4]a.
sup][5],[6],[7] During apoptosis, CASP3 is a key mediator.
To identify the BHD mutation, systematic sequence analysis of the coding exons and intron splice sites of CASP3, LRP2BP and UFSP2 located in the linked region was conducted.
Read-depth analysis for coding and invariant splice-site nucleotides within the BHD-linked locus * Gene Start Stop Strand IRF2 185 395 726 185 308 876 - CASP3 185 570 629 185 548 850 - PRIMPOL 185 570 767 185 616 113 + CENPU 185 615 219 185 655 286 - ACSL1 185 747 268 185 676 749 - HELP 185 940 083 185 941 926 + SLC25A4 186 064 417 186 071 538 + CFAP97 186 080 816 186 125 182 - SNX25 186 131 284 186 285 120 + LRP2BP 186 300 152 186 285 032 - ANKRD37 186 317 840 186 321 390 + UFSP2 186 347 139 186 320 694 - C4orf47 186 350 545 186 370 821 + CCDC110 186 392 913 186 366 338 - PDLIM3 186 456 712 186 421 815 - SORBS2 ([dagger]) 186 877 870 186 506 598 - Mean Gene Annotated Exons, n Coding transcript nucleotides, n IRF2 NM 002199.
Subjects] was negligible for ACTB and CASP3 and was approximately 1 cycle for IL1B and IFNG.
The effects of capsaicin on the expression of BAX and CASP3 are shown in Figure 3B.
Several DNA repair genes, MSH2, RAD18, RAD51, RAD54, XRCC1, XRCC4, and XRCC5, and two apoptosis inducers, CASP3 and HCS, were also in this category.
Observing the interaction network, we found that they clustered in a tight interaction network centered on CASP3 (Caspase-3) and AIFml (Apoptosis-inducing factor 1) which were both closely related to cell apoptosis.
Triptolide downregulated the cell cycle-related genes E2F2 E2F3, E2F5, CDKN2C, CDK7, CDC23, and SMAD3; the MAPK signaling pathway genes FOS, CASP3, JUND, KRAS, MAP2K2; and the Wnt signaling pathway genes WNT4, MYC, and AXIN2.
Thus, these results suggest that hesperidin could induce apoptosis in human colon cancer cells through CASP3 activation.