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It has been shown that endogenous CB1R in the rat brain undergoes palmitoylation and that mutation of C-terminal Cys415 residue prevents receptor palmitoylation .
Our findings support our hypothesis that CB1R blockade restores decreased HVACCs in SM in HFD-fed mice, which at least partly contributes to CB1R blockade induced-protection of body weight control and glucose homeostasis in diet-induced obesity.
Accumulating evidence from clinical trials suggests that CB1R blockade plays a protective role in controlling body weight and glucose homeostasis in humans (20-23).
Stimulation of CB1R with synthetic, high affinity agonists stimulates food intake even in satiated animals .
Other evidences obtained in mice with a deletion of the gene encoding the CB1R ([CB1R.SUP.-/-]) show that these mice are hypophagic and have less visceral and subcutaneous adipose tissue and greater lean mass when compared to native mice .
The cultured cells were also harvested for measuring mRNA and protein levels of CB1R and CB2R at 4 hours of reoxygenation.
In the new study, Kunos tested a new compound, JD5037, which targets CB1R without penetrating the brain.
Zhang and Marsicano now show that mice lacking CB1Rs only on astroglial cells of the brain are protected from the impairments to spatial working memory that usually follow a dose of THC.
Data from a rat model of formalin-evoked pain shows the endocannabinoid system to be involved in distraction-induced antinociception, where distraction is associated with increased levels of the endogenous ligands in the ventral hippocampus, and the administration of a CB1R antagonist attenuates distraction-induced analgesia .
CB1R availability was also increased in the insula in both anorexia and bulimia patients.
Zhang and Marsicano have now shown that mice lacking CB1Rs only on astroglial cells of the brain are protected from the impairments to spatial working memory that usually follow a dose of THC.
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- CB1 receptor
- CB2 receptor
- CBA IPI
- CBA SCE