In the current study, we have investigated the effects of repeated inhalation SS welding dust particles and its soluble forms on Clara/club cells secretory protein (CC16
) in rats and inquired whether NF-[kappa]B and/or c-Jun/AP-1 related pathway were involved in the inflammation that was affected by various factors including calcium influx, oxidative stress and inflammatory cytokines over which the NF-[kappa]B transcription factor was primarily controlled .
Plasma levels of biomarkers, including HMGB1, MCP-1, interleukin-6 (IL-6), plasma neutrophil elastase, and CC16
, were measured and compared between the baseline ([T.sub.1], after anesthesia induction), 1 h after resumption of two-lung ventilation from OLV ([T.sub.2]), and postoperative day 1 ([T.sub.3]).
, an anti-inflammatory protein secreted by the Clara cells of the distal respiratory epithelium, has been proposed as a biomarker of lung epithelial injury.
ELISA was from Novatein Biosciences (Woburn, MA).
In this pilot study, the objective was to determine Clara cell protein (CC16
) concentration in BAL fluid from term and preterm infants with respiratory failure in whom bronchopulmonary dysplasia (BPD) was diagnosed subsequently.
Lung tissue microenvironment has challenged developers of study methodologies, so, although systemic markers have been proposed (CC16
, surfactant proteins A and B, and Krebs von den Lungen-6), they do not yet have sufficient capacity to indicate minor damage, which implies that the processes of the lung itself cannot always be ascertained.
The following key words and subject terms were searched: Clara cell 10-kDa protein CC10 CC16
SCGB1A1 uteroglobin asthma genetic and polymorphism.
Lower plasma CC16
, a natural anti infammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs.
The contributions of the 9 most abundant proteins were: albumin, 26%; surfactant proteins, 13% (including SP-A, 12%); various immunoglobulins, 14%; serotransferrin, 4%; Clara cell protein (CC16
), 4%; lysozyme C, 2%; proteases and inhibitors, 4% (including [[alpha].sub.1]-antitrypsin, 2%); annexins, 1%; and complement factors, 1%.
Although several biomarkers were associated with FEV1 at baseline, only CC16
levels were significantly associated with the rate of change in FE[V.sub.1], with an additional decline of 4 mL/year for each decrease of 1 standard deviation in the level of CC-16.
Researchers measured several biomarkers of respiratory effects after swimming and found changes in only one-a slight increase in serum CC16
, which suggests an increase in lung epithelium permeability.
"The epithelium becomes more permeable, and Clara cell protein CC16
gets into systemic circulation, which is how exposure can be measured," Dr.