Target Full Name Context Pct Score ASH1L ashl (absent, small, or -0.59 > homeotic)-like (Drosophila) 0.99 RICTOR rapamycin-insensitive companion of -0.57 > mTOR 0.99 ITGB8 integrin, beta 8 -0.62 0.98 C20orf194 chromosome 20 open reading frame -0.72 0.97 194 SNF1LK SNF1-like kinase -0.39 0.97 FAM44B family with sequence similarity 44, -0.65 0.95 member B C10orf18 chromosome 10 open reading frame 18 -0.87 0.95 ZCCHC14 zinc finger, CCHC domain containing -0.5 0.94 14 AFF1 AF4/FMR2 family, member 1 -0.25 0.94 EML4 echinoderm microtubule associated -0.42 0.93 protein like 4 LCOR ligand dependent nuclear receptor -0.33 0.93 corepressor
CCDC6 coiled-coil domain containing 6 -0.33 0.92 BNC2 basonuclin 2 -0.32 0.9 Apoptosis signaling is associated with miR-125b predicted targets.
As with ALK and ROS1 rearrangements, RET is activated by rearrangements that fuse the tyrosine kinase domain of RET with coiled-coil dimerization domains of one of a variety of recurring partner genes, including KIF5B (the most common, at 90%), (64,72,73)
CCDC6, (65,74) NCOA (4,62) and TRIM33.