CCDC6

AcronymDefinition
CCDC6Coiled-Coil Domain Containing 6 (antibody)
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Regarding RET, both KIF5B and CCDC6 have been cited as the most frequent partners in surgically resected and advanced NSCLC (18, 20, 31).
Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients
Target Full Name Context Pct Score ASH1L ashl (absent, small, or -0.59 > homeotic)-like (Drosophila) 0.99 RICTOR rapamycin-insensitive companion of -0.57 > mTOR 0.99 ITGB8 integrin, beta 8 -0.62 0.98 C20orf194 chromosome 20 open reading frame -0.72 0.97 194 SNF1LK SNF1-like kinase -0.39 0.97 FAM44B family with sequence similarity 44, -0.65 0.95 member B C10orf18 chromosome 10 open reading frame 18 -0.87 0.95 ZCCHC14 zinc finger, CCHC domain containing -0.5 0.94 14 AFF1 AF4/FMR2 family, member 1 -0.25 0.94 EML4 echinoderm microtubule associated -0.42 0.93 protein like 4 LCOR ligand dependent nuclear receptor -0.33 0.93 corepressor CCDC6 coiled-coil domain containing 6 -0.33 0.92 BNC2 basonuclin 2 -0.32 0.9 Apoptosis signaling is associated with miR-125b predicted targets.
Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates
As with ALK and ROS1 rearrangements, RET is activated by rearrangements that fuse the tyrosine kinase domain of RET with coiled-coil dimerization domains of one of a variety of recurring partner genes, including KIF5B (the most common, at 90%), (64,72,73) CCDC6, (65,74) NCOA (4,62) and TRIM33.
Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology
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