CCKARCholecystokinin A Receptor
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IGFBP 1-3, ODC, CCKAR, GHSR, and IGF1R, are not objects of our interest, since they are not located on chromosome 1.
Examples of these upregulated genes include LALBA [6] (lactalbumin, alpha-), which encodes a principal milk protein that enables lactose production; CCKAR (cholecystokinin A receptor), which encodes a major physiological mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach; HCRTR2 [hypocretin (orexin) receptor 2], which encodes a protein involved in stimulation of food intake; MCHR1 (melanin-concentrating hormone receptor 1), which encodes a protein involved in neuronal regulation of food consumption; and DMP1 (dentin matrix acidic phosphoprotein 1), which encodes an extracellular matrix protein crucial for proper mineralization of bone and dentin (see Table 2 in the online Data Supplement).
6] Human genes: LALBA, lactalbumin, alpha-; CCKAR, cholecystokinin A receptor; HCRTR2, hypocretin (orexin) receptor 2; MCHR1, melanin-concentrating hormone receptor 1; DMP1, dentin matrix acidic phosphoprotein 1; AES, amino terminal enhancer of split; CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); SFTPB, surfactant protein B; FREM2, FRAS1 related extracellular matrix protein 2.