CCKAR

AcronymDefinition
CCKARCholecystokinin A Receptor
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Biological Gene number Partial related methylated genes function Adhesion 580 Sox-2, Shh, Itpkb, Pkd1, Reln, Ptk2b, Nck2, Ass1 Lphn1, Cdh9, Epdr1, Myf5, Pdpn, Has2, Fgfrl1, Fer Secretion 553 Lphn1, Pim3, Fst, Pim3, Pcsk6, Lax1, Sct, Sytl3 Plcd1, Ykt6, Jak1, Stat2, Myc, Csf2, Lifr, Sos1 Proliferation 787 Dixdc1, Lrp6, Edn3, Nkx2, Cyr61, Src, Sox8, Stk4 Ephb1, Sstr3, Rrm2, Tcf3, Grn, Rhoa, Apc, Nox4, Strn Neuronal 473 Bhlhb9, Cckar, Fzd2, Thy1, Pbx3, regeneration Otx2, Lhx8, Btg2 Klhl1, Dlg2, Pak1, Wnt3, Mif, Tctn1, Evl, Ext1, Als2 Axonal 215 Ifrd1, c-Jun, Bcl2, Tnn, Mbp, Slit3, regeneration Ist1, Drgx, Thy1 Unc5c, Ntrk2, Isl1, Ptk2, Dscam, Atl1, Dnm2, Cxcl12 Figure 3: (a) The distribution of differentially methylated regions (DMRs) peaks in different components of genome.
For example, the female mice missing the gene Cckar had lowered sex drives - about two to three times lower than normal females.
[6] Human genes: LALBA, lactalbumin, alpha-; CCKAR, cholecystokinin A receptor; HCRTR2, hypocretin (orexin) receptor 2; MCHR1, melanin-concentrating hormone receptor 1; DMP1, dentin matrix acidic phosphoprotein 1; AES, amino terminal enhancer of split; CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); SFTPB, surfactant protein B; FREM2, FRAS1 related extracellular matrix protein 2.
Otros fuertes candidatos son el gen del coactivador 1 del receptor gamma activado por proliferadores peroxisomicos (PPARGC1) y el gen del receptor tipo A de la colecistoquinina (CCKAR), ubicados en la misma region (21, 22).