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CCL5CC Chemokine Ligand 5
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Cytokine and chemokine profiling of colon biopsies from mice confirmed a significant interventive treatment effect of anti-IL-21 mAb on chemokine and Th17-related parameters (KC, CCL3, CCL5, IL-17, TNF[alpha], IFN-[gamma], CCL2, and IP-10) (Figure 12).
Ben-Baruch, "The inflammatory chemokines CCL2 and CCL5 in breast cancer," Cancer Letters, vol.
Further, soluble factors, such as CCL2 and CCL5 that are produced by the cancer cells and stroma cells, can increase macrophage infiltrate (2).
Control of transplant tolerance and intragraft regulatory T cell localization by myeloid-derived suppressor cells and CCL5. J Immunol 2012; 188: 4209-4216, doi: 10.4049/ jimmunol.1101512.
Animal experiments revealed that BabA could stimulate the inflammatory cells to release more interleukin-8, CCL5 proinflammatory cytokines and precancer-related factors (CDX2 and MUC2).
Serum levels of seven cytokines, IL-10, IL-17, CCL2, CCL5, CXCL10, G-CSF, and GM-CSF, were higher in the patient than in controls, while levels of IL-2, IL-8, CCL11, and VEGF were lower (Table 2).
These include CXCL1 (Gro-[alpha]), CCL2, CCL7 (MCP-1, MCP-3), and CCL5 (RANTES), which have also been implicated in various behavioral impairments including anxiety, depression, and LM [36-38].
Chemokines MCP-1 (monocyte chemoattractant protein-1; CCL2) and RANTES (regulated on activation normal T-cell expressed and secreted; CCL5) bind to receptors CCR2 and CCR5, respectively.
Rueland et al., "Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice," The Journal of Clinical Investigation, vol.
Chung, "Loss of RUNX3 expression promotes cancer-associated bone destruction by regulating CCL5, CCL19 and CXCL11 in non-small cell lung cancer," The Journal of Pathology, vol.
RANTES (CCL5) is associated with diabetes mellitus type 1 both genetically and functionally [12].
Regulated on activation, normal T-cell expressed and secreted (RANTES), known as chemokine ligand 5 (CCL5), [sup][5] is produced by a variety of cell types including T-cells and platelets.