This study investigated the histological grade, growth fraction and KIT expression pattern of 39 CCMTs previously classified as intermediate grade, allowing the identification of a group of potentially aggressive tumors.
Despite being considered the main tool in the evaluation of CCMTs for at least 40 years (BOSTOK et al., 1973; PATNAIK et al., 1984; KIUPEL et al., 2011), the sole use of histopathology has been proven to be ineffective for the prognostication of CCMTs (KIUPEL et al., 2004; KIUPEL et al., 2011).
Ever since, this supplementary technique has been incorporated as a new variable in the assessment of the biological behavior of CCMTs. WEBSTER et al.
The use of Ki-67, a nuclear protein expressed in cycling cells (YARDEN et al., 1987), as a cellular proliferation marker in CCMTs is well established in the literature (SCASE et al., 2006; WEBSTER et al., 2007; VASCELLARI et al., 2012).
This study was important to identify limitations and to confirm the applicability of these different techniques on a routine diagnostic basis in Brazil; thus, encouraging the use of these methods on the prognostication of CCMTs from this country.
A positive CCMT (PCR+) and a negative CCMT (ITD) for mutations were included as controls.