CCN2Connective Tissue Growth Factor (also known as CTGF)
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Wang et al., "Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma," Journal of Experimental & Clinical Cancer Research, vol.
Suda et al., "Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)," Clinica Chimica Acta, vol.
Brigstock, "Expression of connective tissue growth factor (CCN2) in desmoplastic small round cell tumour," Journal of Clinical Pathology, vol.
Furthermore, CCN2 upregulation has been widely observed in reactive gliosis adjacent to the site of mechanical injuries caused by stab wound in rodents and also in the brain tissue of stroke patients [137] and following traumatic brain injury (TBI) [136].
Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN family.
Mechanical stretch modulates the promoter activity of the profibrotic factor CCN2 through increased actin polymerization and NF-kappaB activation.
Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): Immediate-early gene products expressed in atherosclerotic lesions.
CTGF is a 36-38 kd cysteine-rich, heparin-binding protein that belongs, with Cyr61 and NOV, to the CCN family of proteins regulated by transforming growth factor [beta] (TGF-[beta]) and is also designated CCN2 (2).
Sugito et al., "Regulation of CCN2 gene expression and possible roles in developing tooth germs," Archives of Oral Biology, vol.
Vozenin-Brotons, "Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-(31," American Journal of Physiology.