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CCR2C-C Chemokine Receptor 2 (gene)
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References in periodicals archive ?
Simpson, "Evaluation of a novel chemokine receptor 2 (CCR2)-antagonist in painful diabetic polyneuropathy," Scandinavian Journal of Pain, vol.
Hezel et al., "Overall survival in a trial of orally administered CCR2 inhibitor CCX872 in locally advanced/metastatic pancreatic cancer: correlation with blood monocyte counts," Journal of Clinical Oncology, vol.
For instance, adipose tissue macrophages from CCR2 knockout mice are polarized to the M2-like macrophages, even after obesity and CCR2 knockout mice were found to be protected from diet-induced insulin resistance [145, 160].
Abbreviations: Ag: antigen; AMP: anti-microbial peptide; APC: Antigen presenting cell; ATF6: activating transcription factor 6; CagA: cytotoxin-associated gene A; CARD: caspase activation and recruitment domain; CCKR: cholecystokinin receptor; CCL2: C-C motif chemokine ligand 2; CCR2: C-C chemokine receptor type 2; Cdx2: caudal-type homeobox protein 2; cIAP: cellular inhibitor of apoptosis protein; CXCL: C-X-C motif chemokine ligand; DAMP: damage-associated molecular pattern; iE-DAP: [gamma]-D-glutamyl meso-diaminopimelic acid; ER: endoplasmic reticulum; GI: gastrointestinal; H.
CVC is a once-daily, oral, Phase III ready potent immunomodulator that blocks two chemokine receptors, CCR2 and CCR5, which are involved in inflammatory and fibrogenic pathways.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
Among all protein receptors measured, CXC3R1 showed the highest relative expression, whereas the common receptor for IL8/CXCL8, GRO/CXCL1, 2, and 3, NAP2/CXCL7 and ENA78/CXCL5 (CXCR1, CXCR2), MCP1/CCL2 (CCR2), and RANTES/CCL5 (CCR3) receptors did not have detectable expression (Figure 5).
The N-terminal is rich in tyrosine and acidic amino acids, and its coding gene is located on 3p21 chromosome along with groups of other chemokine coding genes such as CCR1, CCR2, CCR3, and XCR1 [6].
Cassis, "Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice," Clinical Science, vol.
Chemokines MCP-1 (monocyte chemoattractant protein-1; CCL2) and RANTES (regulated on activation normal T-cell expressed and secreted; CCL5) bind to receptors CCR2 and CCR5, respectively.
Berry supplementation in the form of juice, powder, or extract has been shown to decrease serum levels of interleukin- (IL-) 12, monocyte expression of monocyte-to-macrophage differentiation-associated (MMD) and C-C motif chemokine receptor 2 (CCR2), and the overall inflammation score [98] and to improve endothelial function measured by the reactive hyperemia index [99] in MetS patients.
Macrophages are attracted to the site of injury by MCP-1 and its receptor CCR2. Blocking MCP-1/CCR2 pathway was shown to prevent kidney fibrosis through reducing recruitment of M1 inflammatory macrophages [18].