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CCR4C-C Chemokine Receptor 4 (gene)
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Based on the network and modular analysis, seven (ADORA3, TLR7, IRF4, CCR4, RTN1, GAPT, and GRAP2) and ten (GNAO1, ISM1, CILP, SLIT2, SCRG1, TNFAIP8L3, hsa-mir-183, sa-mir-942, MIR345 and HCG18) candidate factors with top significance of COX univariate regression were identified in the yellow and turquoise module, respectively.
Besnard et al., "Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice," PLoS One, vol.
Moreover, the migration of [CD4.sup.+] [CD25.sup.+] T cells to periodontitis that affected gingival tissues seemed to be dependent on CCL17 and CCL22 expression by the local inflammatory infiltrate, which recruits Treg expressing CCR4 or CCR8 [37, 38].
Further, lung DCs in vitro have the option to imprint the expression of gut-homing integrin [alpha]4[beta]7 and CCR9 (lung-homing integrin is CCR4 [84]) on cocultured T cells in vitro and on adoptively transferred cells in vivo, which guides their migration to the GI tract [85].
The CXC chemokine receptor CXCR3 is expressed in Th1 cells, whereas the CC chemokine receptor CCR4 is expressed in Th2 cells [12-14].
When IFN type 1 is activated, it induces production of various inflammatory chemokines, including CXCL9 and CXCL10, recruits chemokines such as CLA, E-selectin, CCR4, and CXCR3 to diseased skin, and causes local inflammation [27].
Global Markets Direct's, 'C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4) - Pipeline Review, H1 2016', provides in depth analysis on C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4) targeted pipeline therapeutics.
Increased CCR4 expression in cutaneous T cell lymphoma.
The tally runs: St Helens 30, Huddersfield 16 (SLR1, 5/2/16); St Helens 22, Huddersfield 28 (SLS8-R3, 20/8/15); St Helens 35, Huddersfield 34 (SLR21, 10/7/15); Huddersfield 8, St Helens 11 (SLR10, 12/4/15); Huddersfield 17, St Helens 16 (SLR27, 12/9/14); St Helens 41, Huddersfield 22 (SLR14, 23/5/14); Huddersfield 16, St Helens 17 (CCR4, 6/4/14); Huddersfield 25, St Helens 16 (SLR17, 3/6/13); St Helens 4, Huddersfield 40 (SLR1, 2/2/13); St Helens 46, Huddersfield 12 (SLR22, 29/7/12).
Subsequently, CCR4 guides the migration of these Tregs within the inflamed liver.
MDC, a CC chemokine, is a potent chemoattractant which activated Th2 lymphocytes via the chemokine receptor CCR4,4 and its receptor CC chemokine receptor 4 (CCR4) preferentially
CCR1, CCR3, and CCR4 were up-regulated when PBMC was co-cultured with UL128 at low concentration (10 ng/mL).