Again, articular homing proves to be enhanced by the presence of CCL20 and its ligand CCR6
, with treatment with anti-CCR6
antibodies being inhibitory .
28),(30) In particular, rs3093024 in the CCR6
gene was the second largest genetic risk allele in a Japanese RA population.
Expression of CCR6
and CD83 by cytokine-activated human neutrophils.
sup] Tc17 cells are shown to share some phenotypical properties with Th17, including retinoic acid receptor-related orphan receptor at, CCR6
, and IL-23R, and express tumor necrosis factor-a (TNF-a), IL-21, and IL-22.
47),(68),(69) The interaction between chemokines produced in the interfollicullar region of the PPs and chemokine receptors, such as between CCL19 and CCR7 and between CCL20 and CCR6
, plays an important role in the transport of dendritic cells to T cell zones.
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6