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With regard to the CCL20, CCR6, and MAdCAM-1 gene expression profiles, D-FL is similar to MALT lymphoma, and it was hypothesized that increased expression of CCL20 and MAdCAM-1, along with coexpression of CCL20 and CCR6, might play an important role in tumorigenesis.
de Paiva, "Chemokine receptors CCR6 and CXCR3 are necessary for [CD4.sup.+] T cell mediated ocular surface disease in experimental dry eye disease," PLoS One, vol.
Again, articular homing proves to be enhanced by the presence of CCL20 and its ligand CCR6, with treatment with anti-CCR6 antibodies being inhibitory [59].
Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling.
CCR6. In 2010, chemokine (C--C motif) receptor 6 (CCR6) was identified as an RA-associated gene in Asian and European populations.
Dwinell, "CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells," The Journal of Biological Chemistry, vol.
Bykovskaia et al., "[beta]-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6," Science, vol.
IL-17 producing T cells have been reported to express mainly CCR2 [120], CCR6 [121], and CXCR3 [122].
Dendritic cells and T cells typically express CCR6, the receptor for MIP-3[alpha], but neutrophils can be induced to express CCR6 in the presence of TNF[alpha] (Yamashiro et al.
Furthermore, targeting antigens to chemokine receptors [1] on DCs (CCR1, CCR2, CXCR4, CCR5, CCR6, and CXCR1) generates enhanced immune responses in vitro and in vivo.
Contact sensitizers downregulate the expression of the chemokine receptors CCR6 and CXCR4 in a skin dendritic cell line.