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CCR8C-C Chemokine Receptor 8 (gene)
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What is significant, though, is the CPA textual variant between the presence (CCR8) and absence ([CSROe]) of a pronoun in front of the Perfect verb.
There are also at least four instances where the pronoun is added to the Participle in sentences where the subject possibly consists of relative clauses (Mk 1:7 CCR1; Lk 9:48 [CSRSe]; Jn 13:20 CCR8; 15:23 CCR8).
(61) Notably, malignant melanoma cells often express high levels of CCR8 and use CCL1-CCR8 to enter into the lymph node parenchyma, forming lymph node metastases.
Our findings suggest that this may be due in part to alterations in CCR8 expression, which plays a key role in T cell homing to lung parenchyma and bronchial epithelium and has been implicated as an important factor in allergic inflammation and normal immune homeostasis in asthma [36-40].
However, Mo-DCs also express CCR8, indicating--like CCR7--its role in DC migration from skin to the lymph node (14).
TI-Treg cells express a few distinct genes, including those encoding chemokine receptor CCR8 and type I interferons.
Lang et al., "Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells," The Journal of Experimental Medicine, vol.
In contrast to ALK+ ALCL, there was also lower expression of cytotoxic molecules, cathepsins, and Th17 cell-associated molecules, and higher expression of some cytokines/receptors (CCL1, CCL22, CCR8, CCR4, IL-13RA2, CXCL14, TGF-bR1) and antiapoptotic molecules (BCL2, BIRC6, BIC), and lower expression of some proapoptotic genes (BAX, BCL2L1, BNPIP3).
We also examined the expression of various chemokine receptors by RPE cells using multiplex PCR kits (Human chemokine receptor CCR kit-1 and kit-2, Maxin Biotech Inc., San Francisco, CA, USA) designed to detect the expression of human CCR1, CCR2, CCR3, CCR4, CCR5, CCR8, V28, CCR11, CCR6, CCR7, and GAPDH genes by identifying PCR products of 500 bp (GAPDH), 363 bp (CCR1), 318bp (CCR3), 287bp (CCR4), 246bp (CCR5), 163bp (CCR2), 428 bp (CCR8), 349bp (V28), 302bp (CCR11), 259bp (CCR6), and 214bp (CCR7).
The circulating monocytic [CD33.sup.high] [CD11b.sup.+] and granulocytic [CD33.sup.low] [CD11b.sup.+] myeloid cell subset as well as [CD11b.sup.+] tumor infiltrating TAMs showed increased expression of the CCL1 chemokine receptor CCR8. The tumor infiltrating [CD11b.sup.+][CCR8.sup.+] myeloid subset produced significant amount of proinflammatory IL6 and angiogenic VEGF and induced the differentiation of [CD4.sup.+][FoxP3.sup.+] regulatory T-cells [44].
Immature DCs are distributed in almost every peripheral tissue and express several chemokine receptors including CCR1, CCR2, CCR4, CCR5, CCR6, CCR8, and CXCR4, with a high capacity to endocytose various materials [22].
It has been found that CCR5, CXCR3, and CXCR6 were preferentially, but not exclusively, expressed on Th1 cells, while CCR3, CCR4, CCR8, and CRTh2 (prostaglandin D2 receptor) were associated with Th2 cells [36, 37, 45, 54].