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CD21Cluster of Differentiation 21 (glycoprotein)
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These tumors can be ruled out by immunohistochemical studies, particularly because the cells of none of these tumors express CD21, CD35, Ki-M4p, or Ki-FDRC1p.
Histologically, it will appear very similar to D-FL when it is grades 1 to 2, but the staining pattern of CD21 of the germinal centers will be more diffusely positive in NFL compared with D-FL.
As discussed above, stains for CD21, BCL6, and CD10 often highlight evidence of follicular colonization.
(52) CD21 and another dendritic cell antigen, CD35, but not CD23, can aid in the diagnosis of MALT lymphoma in 2 ways.
(5,25,27) CD21 expressed on FDCs is a well-known EBV receptor, and EBV can transform FDC cell lines in vitro.
Most cases also expressed conventional FDCS markers, including CD21, CD35, CD23, and clusterin.
Finally, CD21 highlights expanded but intact follicular dendritic cell meshwork within neoplastic follicles.
The virus is transmitted by close contact, frequently through saliva, and EBV uses the CD21 receptor on the surface of B cells to gain entry into cells.
Follicular dendritic cell sarcomas generally demonstrate the immunophenotype of nonneoplastic follicular dendritic cells and are usually positive for dendritic cell markers CD21 (C3b complement receptor), CD23, and/or CD35 (C3d complement receptor), exhibiting cell membrane staining, although cytoplasmic staining can also be seen.
Staining with follicular dendritic cell markers (eg, CD21, CD23) may be of benefit; follicular dendritic cell networks are absent in TCHRLBCL but are present in cases of NLPHL.
(6) There may be occasional focal CD21 expression, although the majority are negative for this.