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CD38Cluster of Differentiation 38 (glycoprotein)
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Caption: Figure 5: CD38 deficiency promotes expressions of NOX4 and decreases overloading of intracellular [Ca.sup.2+].
hAM-MSCs also down regulated the expression of activation markers on the surface of T lymphocytes, CD38 and HLA-DR.
Figures 3(a), 3(b), and 3(c) show the evolution of the expression of CD38 and CD138 on cultured cells in both conditions.
Under that accord, Genmab will grant Janssen an exclusive worldwide licence to develop and sell daratumumab as well as a backup human CD38 antibody.
A single large cluster observed in the lymphocyte region of the SSC/CD45 side scatter showed a high level of CD45 expression and was composed predominantly of T-cells (CD3+) with moderately high CD38 positivity (T-cell activation marker).
The most established marker of immune activation in HIV-1 infection is the expression of CD38 on CD8+ T cells.
Giorgi, Quantitation of CD38 Activation Antigen Expression on [CD8.sup.+] T Cells in HIV-1 Infection Using CD4 Expression on [CD4.sup.+] T Lymphocytes as a Biological Calibrator, Cytometry 33, 123-132 (1998).
The CD38 gene encodes a glycosylated ~45 kDa type II transmembrane protein whose enzymatic activity generates cADPR and adenosine diphosphoribose (ADPR) from [NAD.sup.+] and nicotinic acid adenine dinucleotide phosphate (NAADP) from [NADP.sup.+].
The cluster of differentiation 38 (CD38)/cADPR pathway has been found to play roles in multiple inflammatory processes but its role in sepsis-induced ALI is still unknown.
In addition, elevated levels of CD38, a marker of immune activation on CD4 and CD8 T-cell, predict a rapid decrease of CD4 T-cells and a shorter survival rate, independent of HIV viral loads [8, 9].