CD3ECD3 Antigen, Epsilon Subunit
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In addition, iPSC-MSC EVs significantly decreased the expression of CD3e, CD4, CD4-normalized Icos, and Icosl in SMGs, but not that of CD4-normalized Foxp3 level (Figure 4(f)).
In the cocitation network, CD3D, CD3E, and CD3G, which are compositions of CD3 complex of TCR, interacted with each other to affect the assembly of TCR membrane complex and disturb T-cell responsiveness [27], especially CD3E [28].
[4] Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
DEX, DES, and CPS down-regulated CD3d, CD3e, and CD3g, as well as the coreceptors CD4, CD8a and CD8b, and CD28.
Several statistically significant probes with higher hybridization signals in Jurkat cells, such as those for [CD2.sup.5] CD3E, LCK, GZMA, and CD28, represented genes related to T lymphocytes (24-26).
Recombinant Soluble Dimeric Mouse H-2[L.sup.d]:Ig (DimerX) protein and monoclonal antibodies conjugates [phycoerythrin-Cy-7 (PE-Cy7) Hamster anti-mouse CD3e, phycoerythrin (PE) Rat anti-mouse CD4, and fluorescein (FITC) Rat] were purchased from BD Biosciences (Becton, Dickinson and Company, Franklin Lakes, NJ, USA).
For analysis of CD8 expression, FITC-labeled Mouse Anti-Porcine CD8a (Beckman Coulter) and PE-labeled Mouse Anti-Porcine CD3e (Beckman Coulter) were used under the same condition with CD8.
An NK-cell immunophenotype is most commonly present, including CD2 positive, surface (membranous) CD3 negative, cytoplasmic CD3e positive, and CD56 (neural cell adhesion molecule) positive.
These markers are characterized by their persistent expression within the same lineage: CD19 and CD79a (B-lymphoid lineage), CD3e (T-lymphoid lineage), and myeloperoxidase (MPO; myeloid lineage).
In particular, three clusters (CL1, CL5, and CL6) showed a statistically significant enrichment in "T cell-related" gene categories and included several genes typically associated with T cell-mediated immune responses such as: CD3E, CD4, CD6, CD28, CTLA4, and DUSP2.