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CDC2Cell-Division Cycle 2
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Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation.
By inserting segments from a "library' of human DNA intoyeast cells lacking active cdc2 genes, the researchers isolated human genetic material that could substitute for cdc2 and initiate cell division in the cdc2-deficient yeast cells.
Berberine treatment alone reduced the levels of both cyclin B1 and Cdc2 as compared to control, whereas doxorubicin showed increased level of cyclin B1 without any considerable change in Cdc2 level (Fig.
Elimination of cdc2 phosphorylation sites in the CDC25 phosphatase blocks initiation of M-phase.
44) This may be associated with the activation of p53, downregulation of cyclin A and B1 expression, or the persistent inhibitory phosphorylation of Cdc2 on Tyr15.
Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR.
Genes that are up-regulated by c-myb include Bcl-2, Bcl-XL, c-myc, cyclin A1, cyclin D1, cdc2, and COX2.
Identify the most promising approaches to kinase modulation in cancer and other diseases by examining drug targets including ABL1, EGFR, ERBB2, FLT3, KIT, PDGFRA, PDGFRB, FLT1, FLT4, KDR, JAK2, MET, AKT1, CDC2, CDK2, AURKA, AURKB, PLK1, FRAP1 and PIK3CA.
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system.
Using antibodies to specific phosphorylation sites on vimentin and GFAP catalyzed by various kinases, including cdc2, CF, Rho, protein kinase C, and aurora-B, investigators have shown that the molecular alteration that causes failure of cytoplasmic cleavage in cultured multinucleated GCs is loss of aurora-B kinase function.