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CDC27Cell Division Control 27 Gene
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The data was confirmed by real time PCR for 10 miRNAs (let-7c, miR-10b, miR-26a, miR-26b, miR-29c, miR-30a, miR-29a, miR-29a, miR-30b, miR-30c, miR-148a, and miR-299), and the target genes were subsequently validated (CDC6, CCNE1, MYBL2, PDCD10, ERBB2IP, SON, STK4, CDC27, PRC1, CDC37, TTK, SKIL, BUB3, and SPIN1).
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.
(310) Differentially expressed genes in ALK+ ALCL included genes encoding classical ALCL markers (ALK, CD30, MUC1 or EMA), immunoregulatory cytokines (IL-26, IL-31RA, IL-9, IL-1R2), Th17 cell-associated molecules (IL-17A, IL-17-F, ROR[gamma]), proliferation associated molecules (CCNA1, AGT, PDE4DIP, UPK1B, CDC27), STAT3-regulated targets (SERPINB3, SERPINB4, SOCS1, SOCS3), genes identified in other tumors (RRAD, RAR[alpha], NRCAM, TMEM158, CA12), cytotoxic molecules (PRF1, GZMB), and immunosuppressive response molecules (LILRA3).