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CIP4CDC42 (Cell Division Control Protein 42) Interacting Protein 4
CIP4International Cooperation for Integration of Processes in Prepress, Press, and Postpress (formerly CIP3)
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A moderate twofold increase in SOD3 activity in tissues markedly increases RAS GTP loading and downstream growth signaling [24, 75], whereas robust supraphysiological SOD3 overexpression decreases RAS, RAC, RHO, and CDC42 activation by regulating the gene expression of regulators of these small GTPases.
LagR = 5'-ACRAAMGACARGTAYTCVGGCA-3'; cell division cycle 42 (CDC42): CDC42.
A crucial role for CDC42 in senescence associated inflammation and atherosclerosis.
PAK is a family of serine/threonine protein kinases that are activated by RAS-related G proteins of 21 kDa (p21) called RAC and CDC42.
miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.
The validated target genes for miR-224 are AP15 (apoptosis inhibitor 5) (21), AP2M1 (adaptor-related protein complex 2, mu 1 subunit) (33), CDC42 [cell division cycle 42 (GTP binding protein, 25 kDa)], CXCR4 [chemokine (C-X-C motif) receptor 4] (30), SMAD4 (SMAD family member 4) (34), SMAD5 (SMAD family member 5) (17), SLMAP (sarcolemma-associated protein) (17), H3.
MCF2 L, which codes for the Rho-specific guanine nucleotide exchange factor Dbs that catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1 has been shown to be associated with knee and hip OA.
50% similarity, 3 main clusters were found that matched with existing species on the basis of multilocus sequence analysis (ITS, CDC42, BT2, and ACT1), i.
5] Genes: PDCD4, programmed cell death 4 (neoplastic transformation inhibitor); TPM1, tropomyosin 1 (alpha); PTEN, phosphatase and tensin homolog; TIMP3, TIMP metallopeptidase inhibitor 3; SOCS1, suppressor of cytokine signaling 1; ZBTB10, zinc finger and BTB domain containing 10; RHOC, ras homolog gene family, member C; CD44, CD44 molecule (Indian blood group);BRMS1, breast cancer metastasis suppressor 1; SOX4, SRY (sex determining region Y)-box 4; TNC, tenascin C; CDC42, cell division cycle 42 (GTP binding protein, 25kDa); CXCR4, chemokine (C-X-C motif) receptor 4; CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1.
CDC42 is also a small GTPase that belongs to the Rho family which has multiple functions in regulating both the microtubule and actin cytoskeleton (Etienne-Manneville and Hall, 2003).
Requirement of CDC42 For Salmonella-induced cytoskeletal and nuclear responses.
Anaplastic large cell lymphoma is a tumor of activated (CD25+, CD30+, CD45RO+, HLA-DR+) T cells, with signaling through RHO-GTPases by ALK activation of VAV1 and CDC42.