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CDC6Cell Division Cycle 6
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They are typically located upstream of a cdc6/orc1 gene, which encodes a putative initiator protein that is homologous to Orc1 of the eukaryotic ORC complex or the helicase loader Cdc6 [38, 39].
Activation of the p38 MAPK/Akt/ ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.
Pre-RC formation involves assembly of a number of proteins such as origin recognition complex (ORC), Cdc6, Cdt1, and MCM 2-7.
Several genes were differentially expressed: either down-regulated in cancer cells (UBE1L, CCND2) or upregulated (CHEK1/CHK1, CCNH, CCNB1, p18-CDKN2C, CDC2, FOXM1, CDC6).
(78) Among genes overexpressed in MM, several were involved in cell cycle checkpoints, such as CDK1/CDC2 (cyclin-dependent kinase 1), CDC6 (cell division cycle 6, a regulator of replication), CDKN2C (cyclin-dependent kinase inhibitor 2C, p18), CCNH (cyclin H), CCNB1 (cyclin B1, controlling the cell cycle at the G2/ M transition), CHEK1 (Chk1 is required for checkpoint-mediated cell cycle arrest in response to DNA damage), and FOXM1 (forkhead transcription factor, a regulator of gene expression in the G2 phase).
Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arseniteinduced cell proliferation.
K6001, a mutant strain of yeast with W303 background expresses CDC6, an essential gene for growth, under control of the mother-specific HO promoter and a galactose-dependent promoter GAL1-10.
Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR.
Pattern 8 was composed of 901 genes that were repressed moderately at 6 hr but highly repressed at 24 hr, including many genes whose products participate in various DNA metabolic events during the cell division cycle, such as ASK, CCNA2, CCNB1, CCNB2, CDK2, CDC2, CDC6, CDC45L, CDC7L, MCMs, RFC subunits, and TOP2A (Mendez and Stillman 2000; Stillman 1996).
Genes that play important roles in the [G.sub.1]/S transition and initiation of DNA replication, including CCNE, CDK2, CDC6, CDC45, CDC7, RFC subunits, and MCM family members, were down-regulated at 6 and 24 hr post-IR as an expected consequence of the p53-dependent induction of CDKN1A (p21Wafl) to enforce the [G.sub.1] checkpoint response.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.g., CCNB1, PLK1) are coordinately induced and reach maximal expression levels between 8 and 24 hr (Figure 6B), consistent with the timing of the histologic changes observed in Figure 6A.
cerevisiae) PCNA 101065_at proliferating cell nuclear antigen MCM2 93112_at mini chromosome maintenance deficient 2 CDC6 103821_at cell division cycle 6 homolog (S.