Hastalarin CDO/BDE, CIYKO, CDDO
degerlendirilmelerinde VSU uygulamasi oncesi, 1.
Kufe, "The novel triterpenoid CDDO
induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism," Molecular Pharmacology, vol.
RE grubu CDDO
'de disa yonelim ve toplam sorun alanlarinda daha yuksek puan aldi.
Olgu ve kontrol grubuna ait CDDO
skorlari Tablo 1'de gorulmektedir.
Six nonprofit organizations affiliated with the county CDDO
Her iki grup arasinda bazi CDDO
alt olceklerinde (ice cekilme, sosyal sorunlar, ice atim ve disa atim sorunlari) istatistiksel olarak anlamli farklilik bulunmustur.
Suh et al., "A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO
), is a ligand for the peroxisome proliferator-activated receptor [gamma]," Molecular Endocrinology, vol.
Cocuklarin PHCOKO puanlari ile CDDO
'den alinan puanlari arasindaki iliski incelendiginde her iki grup icin de PHCOKO ile olculen benlik saygisi duzeyi ile CDDO
ice donuk davranis, disa donuk davranis ve toplam davranis sorunu puani arasinda ters iliski saptanmistir (tumu icin r=-0,25_-0,50, p<0,05) (Tablo 5).
Third, it has been shown that the NQO1 expression is stimulated by the NRF2 activators CDDO
(1-[2-cyano3-,12-dioxooleana-1,9(11)- dien-28-oyl]imidazolide), dh404 (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-9,11-dihydro-trifluoroethyl amide), and bardoxolone methyl and that this effect is abrogated in NRF2-/- mice [5, 8, 23].
Li et al., "The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO
and its derivatives," Blood, vol.
The best-known triterpenoid is bardoxolone methyl [2-cyano-3,12-dioxooleana-1,9(11)- dien-28-oic acid (CDDO
) methyl ester/CDDO-Me/RTA 402/bard], which has a CD value of approximately 1 nM, and is classified as an oral "antioxidant inflammation modulator." Clinical data from a phase 2b trial were partially reported in 2011 .
The Nrf2/ARE activators CDDO
ethylamide and CDDO
3-fluoroethylamide significantly attenuated weight loss, enhanced motor performance, and extended the survival of SOD1G93A mice , although these findings have not been confirmed in a subsequent study in which knocking out Nrf2 gene in SOD1G93A mice had only a modest impact on the course of disease 55].