Lipoplatin (LIPO) is a liposomally encapsulated form of
CDDP [12].
When BALB/c mice were treated with a lower dose of
CDDP (15 mg/kg) after 1000 Bq/m3 radon inhalation, the creatinine level was reduced and the superoxide dismutase content was increased, suggesting that this combination might have a protective effect against the CDDP-induced renal damage.
The dysregulation of calcium homeostasis and calcium signaling is known to contribute to the neurotoxic side effects of
CDDP Particularly, voltage-gated calcium channels are believed to play a role in CDDP-induced neurotoxicity [4].
CDDP has proven to be one of the more efficient anticancer chemotherapeutic agents because it targets multiple intracellular sites in order to induce death in tumor cells (Olszewski & Hamilton, 2010).
He underwent four cycles of systemic chemotherapy with capecitabine (cape)/cisplatin (
CDDP) (cape 2000 mg/ sqm [much greater than] 3,000 mg/body days 1-14,
CDDP 80 mg/ sqm [much greater than] 130 mg/body day 1, every 3 weeks), which resulted in progressive disease.
As induction chemotherapy,
CDDP and DOC were both administered at 60 mg/m2 on day 1 and 5-FU at 600 mg/[m.sup.2] from day 1 to day 5.
The CRT consisted of 50.4 Gy in 28 fractions of radiation and four courses of chemotherapy (
CDDP 60 mg/[m.sup.2] on day 1, 5-FU 750 mg/[m.sup.2] on days 1 to 4).
Our results provide novel insight into the
CDDP resistance of OS, which may help to improve the efficacy of chemotherapy.
Simon Eagle is a senior supply chain consultant with CAMELOT MC in the UK, and a certified instructor of the Demand Driven Institute's
CDDP (Certified Demand Driven Planner).
After the first pathological report as poorly differentiated adenocarcinoma, clinicians decided to start chemotherapy (S-1,
CDDP) as soon as possible due to advanced condition of our patient.
Compared with 5-fluorouracil, bleomycin, and epirubicin, cisplatin (
CDDP) was demonstrated to be a better anticancer drug with high activities and durable responses in NPC therapy in clinical studies [14].
Therefore, we treated him with chemotherapy using cisplatin (
CDDP) and gemcitabine (GEM).
